rje mo

mistress, lady [JV]

foremost lady [RY]

principal/ noble lady [IW]

lady (female correlate of rje = 'lord'), queen (feminine honorific title signifying greatness and/or nobility; 'mistress' has some negative connotations -- English lacks enough honorific titles for females to cover the range of Tibetan ones) [Erick Tsiknopoulos]