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pivotal point; linking principle; linchpin [RB]

1) great pain of disease; 2) light rays; 3) [sharp metal] nail, tack; 4) wear, put on; 5) pain, hurt, afflict [IW]

nail, spike, stake, pang, nail, to wear, put on, to pain, hurt, flash of light, crucial position, crucial points [JV]

peg, nail, tack; a stake [RY]